HDACI-induced thrombocytopenia is caused by its unexpected target

Exp Hematol. 2012 Sep;40(9):695-7. doi: 10.1016/j.exphem.2012.07.001. Epub 2012 Jul 4.

Authors

Toshio Kitamura¹, Daichi Inoue

Affiliation

¹ Division of Cellular Therapy/Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. [email protected]

PMID: 22771790
DOI: 10.1016/j.exphem.2012.07.001

No abstract available

MeSH terms

Acetylation / drug effects
Blood Platelets / cytology
Blood Platelets / metabolism
Cell Proliferation / drug effects
Cells, Cultured
Histone Deacetylase Inhibitors / adverse effects
Histone Deacetylase Inhibitors / pharmacology*
Humans
Hydroxamic Acids / adverse effects
Hydroxamic Acids / pharmacology*
Indoles / adverse effects
Indoles / pharmacology*
Megakaryocytes / cytology
Megakaryocytes / metabolism
Panobinostat
Thrombocytopenia / chemically induced
Thrombocytopenia / metabolism*
Thrombopoiesis / drug effects
Tubulin / metabolism*

Substances

Histone Deacetylase Inhibitors
Hydroxamic Acids
Indoles
Tubulin
Panobinostat