Acute severe thrombocytopenia following non-ionic low-osmolarity intravenous contrast medium injection

Korean J Radiol. 2012 Jul-Aug;13(4):505-9. doi: 10.3348/kjr.2012.13.4.505. Epub 2012 Jun 18.

Abstract

Intravenous contrast medium (ICM) rarely induces anaphylactic reactions, including urticaria, hypotension and respiratory failure. Even the most modern ICM may cause such adverse events. Thrombocytopenia has been reported as an extreme rare consequence of ICM. Here we report on a case of a 72-year-old male patient with a self-limiting severe acute thrombocytopenia following administration of intravenous non-ionic low-osmolarity contrast medium. No such low platelet count has ever been reported. We also present a review of the literature.

Keywords: Immunoallergic mechanism; Intravenous contrast material; Thrombocytopenia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Comorbidity
  • Contrast Media / administration & dosage*
  • Contrast Media / adverse effects*
  • Contrast Media / chemistry
  • Diagnosis, Differential
  • Humans
  • Injections, Intravenous
  • Kidney Diseases / diagnostic imaging
  • Male
  • Osmolar Concentration
  • Thrombocytopenia / chemically induced*
  • Tomography, X-Ray Computed
  • Triiodobenzoic Acids / administration & dosage*
  • Triiodobenzoic Acids / adverse effects*
  • Triiodobenzoic Acids / chemistry

Substances

  • Contrast Media
  • Triiodobenzoic Acids
  • ioversol