Abstract
Two unique cis-fused streptothricins (1 and 2) were isolated from the culture broth of Streptomyces sp. I08A 1776. Their structures were determined by MS, CD, and 1D and 2D NMR spectroscopic data analysis. Compound 2 showed weak antibacterial activities against Bacillus subtilis and Enterococcus faecalis with MIC values of 32 and 64 μg ml(-1), respectively.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acids / chemistry
-
Amino Acids / isolation & purification
-
Anti-Bacterial Agents / chemistry*
-
Anti-Bacterial Agents / isolation & purification*
-
Bacillus subtilis / drug effects
-
Culture Media / chemistry
-
Enterococcus faecalis / drug effects
-
Lactams / chemistry
-
Lactams / isolation & purification
-
Magnetic Resonance Spectroscopy
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Streptomyces / chemistry*
-
Streptomyces / growth & development
-
Streptomyces / metabolism
-
Streptothricins / chemistry*
-
Streptothricins / isolation & purification*
Substances
-
Amino Acids
-
Anti-Bacterial Agents
-
Culture Media
-
Lactams
-
streptolidine
-
Streptothricins