Abstract
The transfer of T cell receptor (TCR) genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described, but their protective function in vivo has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14 TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective activities in both viral and bacterial infection models in mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens / metabolism
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Antigens, Viral / chemistry*
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CD8-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / virology*
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Cell Membrane / metabolism
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Cytokines / metabolism
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Flow Cytometry / methods
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Glycoproteins / chemistry*
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Interferon-gamma / metabolism
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Listeria monocytogenes / metabolism
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Lymphocytes / cytology
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Lymphocytic choriomeningitis virus / metabolism*
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Mice
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Peptide Fragments / chemistry*
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Phenotype
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Receptors, Antigen, T-Cell / genetics*
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Receptors, Antigen, T-Cell / metabolism
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Retroviridae / metabolism
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Spleen / metabolism
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Viral Proteins / chemistry*
Substances
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Antigens
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Antigens, Viral
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Cytokines
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Glycoproteins
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Peptide Fragments
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Receptors, Antigen, T-Cell
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Viral Proteins
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glycoprotein peptide 33-41, Lymphocytic choriomeningitis virus
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Interferon-gamma