Abstract
Six patients with an aggressive leukemia/lymphoma disorder had a t(14;18) as well as either a t(8;14) (three patients) or a t(8;22) (three patients). Leukemia cells from all three patients with the t(8;22) had a mature B cell phenotype (Smlg + and TdT-), whereas two of three patients with the t(8;14) had a pre-B phenotype and were Smlg-. None of the patients with the t(8;22) had a prior history of follicular lymphoma, whereas two of the three patients with the t(8;14) had had a follicular lymphoma. The clinical, cytogenetic, and morphologic characteristics of these six patients along with eight previously reported cases with both the t(14;18) and the t(8;14), the t(8;22) or the t(2;8) are discussed.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Adult
-
Aged
-
Blast Crisis / genetics
-
Burkitt Lymphoma / genetics
-
Burkitt Lymphoma / pathology
-
Chromosome Deletion
-
Chromosomes, Human, Pair 14 / ultrastructure*
-
Chromosomes, Human, Pair 22 / ultrastructure*
-
Chromosomes, Human, Pair 8 / ultrastructure*
-
Female
-
Gene Rearrangement
-
Genes, Immunoglobulin
-
Humans
-
Immunophenotyping
-
Lymphoma, Follicular / genetics
-
Lymphoma, Follicular / pathology
-
Lymphoma, Non-Hodgkin / genetics*
-
Lymphoma, Non-Hodgkin / pathology
-
Male
-
Middle Aged
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
-
Translocation, Genetic*