The role of single nucleotide polymorphism of D2 dopamine receptor gene on major depressive disorder and response to antidepressant treatment

Yingcheng Wang; Xiang Liu; Yue Yu; Yuanyuan Han; Jinxue Wei; David Collier; Tao Li; Xiaohong Ma

doi:10.1016/j.psychres.2012.06.024

The role of single nucleotide polymorphism of D2 dopamine receptor gene on major depressive disorder and response to antidepressant treatment

Psychiatry Res. 2012 Dec 30;200(2-3):1047-50. doi: 10.1016/j.psychres.2012.06.024. Epub 2012 Jul 15.

Authors

Yingcheng Wang¹, Xiang Liu, Yue Yu, Yuanyuan Han, Jinxue Wei, David Collier, Tao Li, Xiaohong Ma

Affiliation

¹ The Psychiatric Laboratory & the Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.

PMID: 22796099
DOI: 10.1016/j.psychres.2012.06.024

Abstract

The study analyzed the effect of dopamine 2 receptor gene (DRD2) polymorphism on the risk for major depressive disorder (MDD) and the response to selective serotonin reuptake inhibitors (SSRIs). The results suggest that the DRD2 gene may play a role on MDD susceptibility and the onset-time of antidepressant response.

MeSH terms

Adult
Antidepressive Agents / therapeutic use*
Depressive Disorder, Major / drug therapy*
Depressive Disorder, Major / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide*
Receptors, Dopamine D2 / genetics*
Selective Serotonin Reuptake Inhibitors / therapeutic use
Treatment Outcome

Substances

Antidepressive Agents
Receptors, Dopamine D2
Serotonin Uptake Inhibitors