Comparative analysis of esterase activities of human, mouse, and rat blood

Bull Exp Biol Med. 2011 Nov;152(1):73-5. doi: 10.1007/s10517-011-1457-y.
[Article in English, Russian]

Abstract

Acetylcholinesterase, butyrylcholinesterase, carboxylesterase, and paraoxonase activities in human, mouse, and rat blood were measured. The proportions of these enzymes activities differed significantly. In humans, the most significant were cholinesterase activities, while in rats and mice the contribution of carboxylesterase activity was the greatest. High arylesterase activity of paraoxonase was observed in all cases. Species-specific differences should be taken into consideration when carrying out preclinical trials on rodents for optimization of the pharmacokinetic characteristics of drugs containing complex ester groups.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / blood*
  • Adult
  • Animals
  • Animals, Outbred Strains
  • Aryldialkylphosphatase / blood*
  • Butyrylcholinesterase / blood*
  • Carboxylesterase / blood*
  • Female
  • Humans
  • Male
  • Mice
  • Middle Aged
  • Rats
  • Rats, Wistar
  • Species Specificity

Substances

  • Carboxylesterase
  • Acetylcholinesterase
  • Butyrylcholinesterase
  • Aryldialkylphosphatase