Passive and active target delivery of drugs to ischemic myocardium

M M Galagudza; D V Korolev; D L Sonin; I V Alexandrov; S M Minasian; V N Postnov; E B Kirpicheva; G V Papayan; I S Uskov

doi:10.1007/s10517-011-1466-x

Passive and active target delivery of drugs to ischemic myocardium

Bull Exp Biol Med. 2011 Nov;152(1):105-7. doi: 10.1007/s10517-011-1466-x.

[Article in English, Russian]

Authors

M M Galagudza¹, D V Korolev, D L Sonin, I V Alexandrov, S M Minasian, V N Postnov, E B Kirpicheva, G V Papayan, I S Uskov

Affiliation

¹ V. A. Almazov Center of Heart, Blood, and Endocrinology, St. Petersburg, Russia. [email protected]

PMID: 22803053
DOI: 10.1007/s10517-011-1466-x

Abstract

Silica nanoparticles as carriers for targeted drug delivery to the heart were studied. Studies of hemodynamic parameters of rats after intravenous infusion of silica nanoparticles showed no acute toxicity. Intravenous infusion of silica nanoparticles to animals with ischemia-reperfusion of the myocardium led to accumulation of the nanoparticles in the focus of injury, which attests to possibility of passive targeted drug delivery to the myocardium.

MeSH terms

Animals
Blood Pressure / drug effects
Drug Carriers / pharmacokinetics*
Drug Carriers / toxicity
Fluorescein / pharmacokinetics
Fluorescent Dyes / pharmacokinetics
Heart Rate / drug effects
Materials Testing
Myocardial Ischemia / drug therapy*
Myocardium / metabolism
Nanoparticles
Particle Size
Rats
Rats, Wistar
Silicon Dioxide / pharmacokinetics*
Silicon Dioxide / toxicity
Tissue Distribution

Substances

Drug Carriers
Fluorescent Dyes
Silicon Dioxide
Fluorescein