Effect of transplantation of bone marrow monomuclears on angiogenesis in rats

T Kh Fatkhudinov; J P Baikova; G B Bolshakova; T B Buharova; T K Dubovaya; L V Kaktursky; D V Goldshtein

doi:10.1007/s10517-011-1469-7

Effect of transplantation of bone marrow monomuclears on angiogenesis in rats

Bull Exp Biol Med. 2011 Nov;152(1):120-3. doi: 10.1007/s10517-011-1469-7.

[Article in English, Russian]

Authors

T Kh Fatkhudinov¹, J P Baikova, G B Bolshakova, T B Buharova, T K Dubovaya, L V Kaktursky, D V Goldshtein

Affiliation

¹ Laboratory of Growth and Development, Research Institute of Human Morphology, Russian Academy of Medical Sciences, Russian State Medical University, Moscow, Russia. [email protected]

PMID: 22803056
DOI: 10.1007/s10517-011-1469-7

Abstract

We studied the effect of non-selective intracoronary transplantation of bone marrow mononuclears on day 30 after acute coronary infarction on angiogenesis in rats. On days 14 and 30 after transplantation of mononuclear cells, stable formation of new vessels was observed. The number of venules considerably increased after transplantation of mononuclear cells, which was seen from increased volume density of blood vessels and their caliber. Stable vascularization after transplantation of mononuclear cells improves blood supply, which is essential for reparation of the myocardium.

MeSH terms

Animals
Bone Marrow Cells / physiology
Bone Marrow Transplantation*
Cicatrix / physiopathology
Coronary Vessels / physiopathology*
Granulation Tissue / blood supply
Male
Myocardial Infarction / pathology
Myocardial Infarction / physiopathology
Myocardial Infarction / therapy*
Myocardium / pathology
Neovascularization, Physiologic*
Rats
Rats, Sprague-Dawley
Regeneration
Venules / physiopathology