Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins

Bull Exp Biol Med. 2012 Mar;152(5):615-8. doi: 10.1007/s10517-012-1590-2.
[Article in English, Russian]

Abstract

Geroprotective peptide T-34 regulates the expression of mRNA for various genes. The development of gastric ulcer is associated with morphological and molecular changes resulting from modulation of the synthesis of antioxidant and anti-inflammatory proteins. Peptide T-34 normalizes the synthesis of these proteins by regulating the expression of the corresponding genes.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / administration & dosage*
  • Clarithromycin / administration & dosage
  • Cystamine / administration & dosage
  • Gastric Mucosa / drug effects*
  • Gastric Mucosa / metabolism
  • Gene Expression Regulation / drug effects*
  • HSP70 Heat-Shock Proteins / genetics
  • HSP70 Heat-Shock Proteins / metabolism
  • Helicobacter pylori / growth & development
  • Male
  • Nitric Oxide Synthase Type I / genetics
  • Nitric Oxide Synthase Type I / metabolism
  • Nitric Oxide Synthase Type II / genetics
  • Nitric Oxide Synthase Type II / metabolism
  • Oligopeptides / administration & dosage*
  • RNA, Messenger / biosynthesis
  • Rats
  • Rats, Sprague-Dawley
  • Signal Transduction / drug effects
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / drug therapy*
  • Stomach Ulcer / genetics
  • Stomach Ulcer / microbiology
  • Transcription Factor RelA / genetics
  • Transcription Factor RelA / metabolism

Substances

  • Anti-Inflammatory Agents
  • HSP70 Heat-Shock Proteins
  • Oligopeptides
  • RNA, Messenger
  • Transcription Factor RelA
  • glutamyl-aspartyl-glycine
  • Nitric Oxide Synthase Type I
  • Nitric Oxide Synthase Type II
  • Nos2 protein, rat
  • Clarithromycin
  • Cystamine