Abstract
Giant cell tumors deriving from synovium are classified into a localized (GCT of tendon sheath; GCT-TS) and diffuse form (diffuse-type GCT, Dt-GCT). We propose a multidisciplinary management based upon a systematic review and authors' opinion. Open excision for GCT-TS and open synovectomy (plus excision) for Dt-GCT is advised to reduce the relatively high recurrence risk. External beam radiotherapy should be considered in severe cases, as Dt-GCT commonly extends extra-articular.
Copyright © 2012 Wiley Periodicals, Inc.
MeSH terms
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Adult
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Antineoplastic Agents / therapeutic use*
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Arthroplasty
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Arthroscopy
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Benzamides
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Chemotherapy, Adjuvant
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Female
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Giant Cell Tumors / complications
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Giant Cell Tumors / diagnosis*
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Giant Cell Tumors / pathology
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Giant Cell Tumors / radiotherapy
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Giant Cell Tumors / surgery
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Giant Cell Tumors / therapy*
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Humans
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Imatinib Mesylate
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Indoles / therapeutic use
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Interdisciplinary Communication*
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Molecular Targeted Therapy* / methods
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Neoplasm Recurrence, Local / diagnosis
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Neoplasm Recurrence, Local / prevention & control
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Piperazines / therapeutic use
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Protein Kinase Inhibitors / therapeutic use
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Protein-Tyrosine Kinases / antagonists & inhibitors
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Pyrimidines / therapeutic use
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Pyrroles / therapeutic use
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Radioisotopes / therapeutic use
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Radiotherapy, Adjuvant
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Sunitinib
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Synovectomy
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Synovial Membrane* / pathology
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Tendons* / pathology
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Tendons* / surgery
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Tenosynovitis / etiology
Substances
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Antineoplastic Agents
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Benzamides
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Indoles
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Piperazines
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Protein Kinase Inhibitors
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Pyrimidines
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Pyrroles
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Radioisotopes
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Imatinib Mesylate
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Protein-Tyrosine Kinases
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nilotinib
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Sunitinib