Abstract
Twenty-three strains of Staphylococcus aureus with borderline resistance to oxacillin were studied. These strains were not detected by the cefoxitin test, tests for penicillin-binding protein 2a (PBP2a), mecA, and mecA(LGA251) were negative, and the strains were genetically unrelated. To detect all strains resistant to oxacillin, laboratories should routinely test for both cefoxitin and oxacillin.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Cefoxitin / pharmacology
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Cluster Analysis
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Drug Resistance, Bacterial*
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Electrophoresis, Gel, Pulsed-Field
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Humans
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / isolation & purification
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Microbial Sensitivity Tests / methods
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Molecular Epidemiology
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Molecular Typing
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Oxacillin / pharmacology*
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Penicillin-Binding Proteins / genetics
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Staphylococcal Infections / epidemiology
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Staphylococcal Infections / microbiology*
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Tunisia / epidemiology
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Penicillin-Binding Proteins
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mecA protein, Staphylococcus aureus
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Cefoxitin
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Oxacillin