Treatment of tuberculosis with levofloxacin or moxifloxacin: report of 6 pediatric cases

Pediatr Infect Dis J. 2012 Dec;31(12):1309-11. doi: 10.1097/INF.0b013e318269cc6a.

Abstract

We report 6 pediatric cases of tuberculosis caused by Mycobacterium tuberculosis and treated them with levofloxacin or moxifloxacin in the mother-child unit of a university hospital in France between 2005 and 2011. We assess the clinical efficacy and safety of fluoroquinolones and the benefit-risk ratio for their use as second-line antituberculosis drugs in children and adolescents.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antitubercular Agents / administration & dosage*
  • Antitubercular Agents / adverse effects
  • Aza Compounds / administration & dosage*
  • Aza Compounds / adverse effects
  • Child
  • Child, Preschool
  • Female
  • Fluoroquinolones
  • France
  • Hospitals, University
  • Humans
  • Infant
  • Levofloxacin*
  • Male
  • Moxifloxacin
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / isolation & purification*
  • Ofloxacin / administration & dosage*
  • Ofloxacin / adverse effects
  • Quinolines / administration & dosage*
  • Quinolines / adverse effects
  • Treatment Outcome
  • Tuberculosis, Multidrug-Resistant / drug therapy*

Substances

  • Antitubercular Agents
  • Aza Compounds
  • Fluoroquinolones
  • Quinolines
  • Levofloxacin
  • Ofloxacin
  • Moxifloxacin