Changes in electrokinetic properties of erythrocytes under the influence of pentoxifylline and new hemorheologically active substances

L V Naumenko; V A Kuznetsov; A A Spasov; A V Muravyev; I A Tikhomirova; F A Khaliullin; V A Anisimova

doi:10.1007/s10517-012-1678-8

Changes in electrokinetic properties of erythrocytes under the influence of pentoxifylline and new hemorheologically active substances

Bull Exp Biol Med. 2012 Jun;153(2):209-11. doi: 10.1007/s10517-012-1678-8.

[Article in English, Russian]

Authors

L V Naumenko¹, V A Kuznetsov, A A Spasov, A V Muravyev, I A Tikhomirova, F A Khaliullin, V A Anisimova

Affiliation

¹ Department of Pharmacology, Volgograd State Medical University, Rostov-on-Don, Russia. [email protected]

PMID: 22816085
DOI: 10.1007/s10517-012-1678-8

Abstract

We studied the impact of compounds RU-1202 and SUM-55 on electrophoretic mobility of "young" and "old" erythrocytes fractionated in a density gradient. The test compounds are shown to increase electrophoretic mobility of erythrocytes, compound SUM-55 being superior to the reference drug pentoxifylline.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Benzimidazoles / pharmacology*
Electrophoresis, Polyacrylamide Gel
Erythrocyte Membrane / drug effects
Erythrocyte Membrane / physiology
Erythrocytes / drug effects*
Erythrocytes / physiology*
Male
Pentoxifylline / pharmacology*
Piperidines / pharmacology*
Platelet Aggregation Inhibitors / pharmacology
Rats
Xanthines / pharmacology*

Substances

1,3-dimethyl-7-(2-hydroxy-3-(1-piperidino)propyl)-8-phenylxanthineamine
9-(2-diethylaminoethyl)-2-(4-fluorophenyl)imidazo(1,2-a)benzimidazole
Benzimidazoles
Piperidines
Platelet Aggregation Inhibitors
Xanthines
Pentoxifylline