Abstract
From the MeOH extract of the aerial part of Blumea balsamifera L., a new dihydroflavonol, (2R,3S)-(-)-4'-O-methyldihydroquercetin (1), together with seven known compounds has been isolated. Their structures were elucidated on the basis of spectroscopic data. Compounds 1-4 and 6-8 displayed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and compounds 1, 6 and 8 showed more potent inhibitory activity, with IC₅₀ values ranging from 0.23 to 1.91 µM, than that of a positive control allopurinol (IC₅₀ 2.50 µM).
Copyright © 2012 John Wiley & Sons, Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Asteraceae / chemistry*
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Chemical Fractionation
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Flavonoids / chemistry
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Flavonoids / isolation & purification
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Inhibitory Concentration 50
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Methanol
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Molecular Structure
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Plant Components, Aerial / chemistry
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Plant Extracts / chemistry
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Quercetin / analogs & derivatives*
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Quercetin / chemistry
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Quercetin / isolation & purification
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Structure-Activity Relationship
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Xanthine Oxidase / antagonists & inhibitors*
Substances
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(2R,3S)-(-)-4'-O-methyldihydroquercetin
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Enzyme Inhibitors
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Flavonoids
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Plant Extracts
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quercetin 3-O-methyl ether
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Quercetin
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Xanthine Oxidase
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Methanol