Hollow copper sulfide nanoparticle-mediated transdermal drug delivery

Small. 2012 Oct 22;8(20):3143-50. doi: 10.1002/smll.201200783. Epub 2012 Jul 25.

Abstract

A photothermal ablation-enhanced transdermal drug delivery methodology is developed based on hollow copper sulfide nanoparticles (HCuSNPs) with intense photothermal coupling effects. Application of nanosecond-pulsed near-infrared laser allows rapid heating of the nanoparticles and instantaneous heat conduction. This provides very short periods of time but extremely high temperatures in local regions, with focused thermal ablation of the stratum corneum. The depth of skin perforations can be controlled by adjusting the laser power. Skin disruption by HCuSNP-mediated photothermal ablation significantly increases the permeability of human growth hormone. This technique offers compelling opportunities for macromolecular drug and vaccine delivery.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Animals
  • Copper / chemistry*
  • Drug Delivery Systems / methods*
  • Female
  • Laser Therapy
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Microscopy, Electron, Transmission
  • Skin / drug effects
  • Skin / metabolism
  • Skin Absorption

Substances

  • Copper