An amphiphilic dendrimer for effective delivery of small interfering RNA and gene silencing in vitro and in vivo

Tianzhu Yu; Xiaoxuan Liu; Anne-Laure Bolcato-Bellemin; Yang Wang; Cheng Liu; Patrick Erbacher; Fanqi Qu; Palma Rocchi; Jean-Paul Behr; Ling Peng

doi:10.1002/anie.201203920

An amphiphilic dendrimer for effective delivery of small interfering RNA and gene silencing in vitro and in vivo

Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8478-84. doi: 10.1002/anie.201203920. Epub 2012 Jul 24.

Authors

Tianzhu Yu¹, Xiaoxuan Liu, Anne-Laure Bolcato-Bellemin, Yang Wang, Cheng Liu, Patrick Erbacher, Fanqi Qu, Palma Rocchi, Jean-Paul Behr, Ling Peng

Affiliation

¹ State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, 430072 Wuhan, China.

PMID: 22829421
DOI: 10.1002/anie.201203920

Abstract

An amphiphilic dendrimer bearing a hydrophobic alkyl chain and hydrophilic poly(amidoamine) dendrons is able to combine the advantageous features of lipid and dendrimer vectors to deliver a heat shock protein 27 siRNA and produce potent gene silencing and anticancer activity in vitro and in vivo in a prostate cancer model. This dendrimer can be used alternatively for treating various diseases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dendrimers / administration & dosage*
Dendrimers / chemical synthesis
Dendrimers / chemistry*
Gene Silencing*
Genetic Therapy / methods
Genetic Vectors / administration & dosage*
Genetic Vectors / chemistry*
Genetic Vectors / genetics
HSP27 Heat-Shock Proteins / genetics
Humans
Male
Prostatic Neoplasms / genetics
Prostatic Neoplasms / therapy
RNA, Small Interfering / administration & dosage*
RNA, Small Interfering / chemistry*
RNA, Small Interfering / genetics

Substances

Dendrimers
HSP27 Heat-Shock Proteins
PAMAM Starburst
RNA, Small Interfering