Successful treatment of tumor-induced osteomalacia with CT-guided percutaneous ethanol and cryoablation

J Clin Endocrinol Metab. 2012 Oct;97(10):3421-5. doi: 10.1210/jc.2012-1719. Epub 2012 Jul 26.

Abstract

Context: Tumor-induced osteomalacia is a rare condition usually caused by benign mesenchymal tumors. When the tumor can be found, patients are usually managed by wide excision of the tumor.

Objective: We report a 51-yr-old male with clinical and biochemical evidence of tumor-induced osteomalacia caused by a mesenchymal tumor in the right iliac bone. He declined surgery and appears to have been successfully managed by computed tomography-guided percutaneous ethanol ablation and percutaneous cryoablation.

Results: Our patient appears to have had an excellent clinical and biochemical response to computed tomography-guided percutaneous ethanol ablation and percutaneous cryoablation. We found one prior case of image-guided ablation using radiofrequency ablation for tumor-induced osteomalacia.

Conclusions: Although the standard treatment for tumor-induced osteomalacia is wide excision of the tumor, image-guided ablation may be an option in patients who cannot have appropriate surgery or who decline surgery.

Publication types

  • Case Reports

MeSH terms

  • Cryosurgery / methods*
  • Ethanol / therapeutic use*
  • Humans
  • Male
  • Mesenchymoma / complications*
  • Middle Aged
  • Neoplasms, Connective Tissue / complications*
  • Osteomalacia* / drug therapy
  • Osteomalacia* / etiology
  • Osteomalacia* / surgery
  • Solvents / therapeutic use
  • Tomography, X-Ray Computed / methods

Substances

  • Solvents
  • Ethanol