Abstract
Colorectal carcinoma is an extremely rare tumor in childhood. Therefore, the role of adjuvant chemotherapy has not been adequately evaluated in children leading to limited data on safety profile and treatment response after application of novel drugs and novel targeted agents. In this report, we describe a case of colon adenocarcinoma in a 13-year-old girl treated with standard adult treatment as well as novel targeted therapy. This case report illustrates initial good disease control with FOLFOX therapy. On the other hand, targeted therapy revealed no improvement in disease control and good safety profile without significant adverse effects.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / drug therapy*
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Adenocarcinoma / secondary
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Adolescent
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Antibodies, Monoclonal, Humanized / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bevacizumab
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Capecitabine
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / pathology
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Deoxycytidine / administration & dosage
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Deoxycytidine / analogs & derivatives
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Fatal Outcome
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Female
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Fluorouracil / administration & dosage
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Fluorouracil / analogs & derivatives
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Humans
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Leucovorin / administration & dosage
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Organoplatinum Compounds / administration & dosage
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Oxaliplatin
Substances
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Antibodies, Monoclonal, Humanized
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Organoplatinum Compounds
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Oxaliplatin
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Deoxycytidine
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Bevacizumab
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Capecitabine
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Leucovorin
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Fluorouracil