Abstract
Three mononuclear copper(II) complexes, [Cu(tpy)Cl(2)] 1, [Cu(tpy)(NO(3))(2)(H(2)O)] 2 and [Cu(Ptpy)Cl(2)]·H(2)O·HCl 3 have been synthesised and characterized by various spectroscopic techniques and single crystal X-ray diffraction. Complexes 1 and 3 have five coordinate geometry in solid state, whereas complex 2 has six coordinate geometry. Mass spectral and EPR evidence suggest that in solution all the three complexes exist predominantly as a four coordinate species. Molecular modelling and DNA cleavage studies indicate that complexes 1 and 2 are DNA minor groove binders, whereas 3 is an intercalator. All the three complexes show nuclease activity in the presence of hydrogen peroxide. The three complexes have been found to be cytotoxic towards A549 lung adenocarcinoma cells.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenocarcinoma / drug therapy
-
Adenocarcinoma / metabolism
-
Adenocarcinoma of Lung
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / pharmacology
-
Apoptosis / drug effects
-
Binding Sites
-
Cell Cycle / drug effects
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Coordination Complexes / chemical synthesis*
-
Coordination Complexes / pharmacology
-
Copper / chemistry*
-
Crystallography, X-Ray
-
DNA / chemistry
-
DNA / metabolism*
-
DNA Cleavage
-
DNA, Superhelical / chemistry
-
DNA, Superhelical / metabolism*
-
Deoxyribonucleases / chemistry
-
Deoxyribonucleases / metabolism
-
Electron Spin Resonance Spectroscopy
-
Humans
-
Hydrogen Peroxide / metabolism
-
Lung Neoplasms / drug therapy
-
Lung Neoplasms / metabolism
-
Mass Spectrometry
-
Molecular Docking Simulation
-
Plasmids
-
Pyridines / chemistry*
Substances
-
Antineoplastic Agents
-
Coordination Complexes
-
DNA, Superhelical
-
Pyridines
-
Copper
-
DNA
-
calf thymus DNA
-
Hydrogen Peroxide
-
Deoxyribonucleases