Glucocorticoid sensitivity of T-cell lymphoblastic leukemia/lymphoma is associated with glucocorticoid receptor-mediated inhibition of Notch1 expression

Leukemia. 2013 Feb;27(2):485-8. doi: 10.1038/leu.2012.192. Epub 2012 Jul 13.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / pharmacology
  • Basic Helix-Loop-Helix Transcription Factors / antagonists & inhibitors
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Basic Helix-Loop-Helix Transcription Factors / metabolism*
  • Blotting, Western
  • Chromatin Immunoprecipitation
  • Dexamethasone / pharmacology*
  • Drug Resistance, Neoplasm / genetics*
  • Homeodomain Proteins / antagonists & inhibitors
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism*
  • Humans
  • Mutation / genetics
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • RNA, Messenger / genetics
  • RNA, Small Interfering / genetics
  • Real-Time Polymerase Chain Reaction
  • Receptor, Notch1 / antagonists & inhibitors*
  • Receptor, Notch1 / genetics
  • Receptor, Notch1 / metabolism
  • Receptors, Glucocorticoid / genetics
  • Receptors, Glucocorticoid / metabolism*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcription Factor HES-1
  • Tumor Cells, Cultured

Substances

  • Anti-Inflammatory Agents
  • Basic Helix-Loop-Helix Transcription Factors
  • Homeodomain Proteins
  • NR3C1 protein, human
  • RNA, Messenger
  • RNA, Small Interfering
  • Receptor, Notch1
  • Receptors, Glucocorticoid
  • Transcription Factor HES-1
  • HES1 protein, human
  • Dexamethasone