Amino acids and peptides. XXVII. Synthesis of phytochelatin-related peptides and examination of their heavy metal-binding properties

Chem Pharm Bull (Tokyo). 1990 Sep;38(9):2364-8. doi: 10.1248/cpb.38.2364.

Abstract

Phytochelatin (PC)-related peptides were prepared by a conventional solution method and their heavy metal-binding properties were examined. Different from the Cu2+ and Cu+ -binding properties of metallothionein (MT)-related peptides, the Cu2+ and Cu+ -binding properties of PC-related peptides were fairly dependent on structure. It is of interest that gamma-Glu-Cys-Gly (glutathione) exhibited quite different Cu2+ and Cu+ -binding properties from those of other PC-related peptides and its binding abilities were comparable to those of MT-related peptides. The Cd2+ -binding properties of glutathione were similar to those of Cys, and the Cd2+ -binding abilities of PC-related peptides increased in proportion to the increase of gamma-Glu-Cys peptide unit.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / chemical synthesis*
  • Amino Acids / chemistry
  • Fungal Proteins / chemical synthesis
  • Fungal Proteins / chemistry
  • Fungal Proteins / metabolism
  • Metals / metabolism
  • Molecular Sequence Data
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Peptides / metabolism
  • Plant Proteins / chemical synthesis
  • Plant Proteins / chemistry
  • Plant Proteins / metabolism

Substances

  • Amino Acids
  • Fungal Proteins
  • Metals
  • Peptides
  • Plant Proteins