Molecular characterization of a new lytic bacteriophage isolated from cheese whey

Arch Virol. 2012 Dec;157(12):2265-72. doi: 10.1007/s00705-012-1432-6. Epub 2012 Aug 4.

Abstract

In this study, we isolated and characterized a lytic Lactococcus lactis bacteriophage from the sera of a failed fermentation. The phage was isolated and cultured in L. lactis subsp. cremoris in M17 medium. The isolated bacteriophage was characterized by multiplex PCR, pulsed-field electrophoresis, DNA restriction digestion, analysis of the N-terminal sequence of the phage major structural protein, transmission electron microscopy and sequencing and analysis of a conserved fragment of its genome. Analysis of the viral genome indicates that its genome is composed of a DNA strand of approximately 48 kb in length, and PCR and microscopy confirmed that IL-P1 belongs to the group of 936-type phages in the family Siphoviridae, which is the most abundant type of lactococcal virus in dairy products worldwide. To our knowledge, this is the first report of a virus within this family that has a presumptive genome larger than 40 kb.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cheese / microbiology*
  • DNA, Viral / chemistry
  • DNA, Viral / genetics
  • Electrophoresis, Gel, Pulsed-Field
  • Genome, Viral / genetics
  • Lactococcus lactis / virology*
  • Molecular Sequence Annotation
  • Phylogeny
  • Point Mutation
  • Polymerase Chain Reaction
  • Restriction Mapping
  • Sequence Alignment
  • Siphoviridae / classification*
  • Siphoviridae / genetics
  • Siphoviridae / isolation & purification
  • Siphoviridae / ultrastructure
  • Viral Proteins / chemistry
  • Viral Proteins / genetics

Substances

  • DNA, Viral
  • Viral Proteins