Cyclization strategies to polyenes using Pd(II)-catalyzed couplings of pinacol vinylboronates

Org Lett. 2012 Aug 17;14(16):4282-5. doi: 10.1021/ol3020623. Epub 2012 Aug 6.

Abstract

As a complement to Pd(0)-catalyzed cyclizations, seven Pd(II)-catalyzed cyclization strategies are reported. α,ω-Diynes are selectively hydroborated to bis(boronate esters), which cyclize under Pd(II)-catalysis producing a diverse array of small, medium, and macrocyclic polyenes with controlled E,E, Z,Z, or E,Z stereochemistry. Various functional groups are tolerated including aryl bromides, and applications are illustrated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Cyclization
  • Diynes / chemistry*
  • Esters
  • Molecular Structure
  • Palladium / chemistry*
  • Polyenes / chemical synthesis*
  • Polyenes / chemistry
  • Stereoisomerism
  • Vinyl Compounds / chemistry

Substances

  • Diynes
  • Esters
  • Polyenes
  • Vinyl Compounds
  • vinylboronate ester
  • Palladium