Exploring the endocrine manifestations of DICER1 mutations

Catherine S Choong; John R Priest; William D Foulkes

doi:10.1016/j.molmed.2012.07.003

Exploring the endocrine manifestations of DICER1 mutations

Trends Mol Med. 2012 Sep;18(9):503-5. doi: 10.1016/j.molmed.2012.07.003. Epub 2012 Aug 3.

Authors

Catherine S Choong¹, John R Priest, William D Foulkes

Affiliation

¹ School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, Subiaco, Western Australia 6008, Australia.

PMID: 22867905
DOI: 10.1016/j.molmed.2012.07.003

Abstract

The discovery of each new cancer susceptibility gene answers one set of questions but poses many more. In this article, we outline a recent example: a new cancer syndrome caused by germline mutations in DICER1, responsible for microRNA processing. In particular, we discuss the endocrine manifestations of mutations in this crucial gene.

MeSH terms

Animals
DEAD-box RNA Helicases / genetics*
Germ-Line Mutation*
Humans
Mice
MicroRNAs / chemistry
MicroRNAs / metabolism
Models, Animal
Phenotype
Ribonuclease III / genetics*

Substances

MicroRNAs
DICER1 protein, human
Ribonuclease III
DEAD-box RNA Helicases