Cephalosporin-3'-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms

Nicolas Barraud; Bharat G Kardak; Nageshwar R Yepuri; Robert P Howlin; Jeremy S Webb; Saul N Faust; Staffan Kjelleberg; Scott A Rice; Michael J Kelso

doi:10.1002/anie.201202414

Cephalosporin-3'-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms

Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9057-60. doi: 10.1002/anie.201202414. Epub 2012 Aug 13.

Authors

Nicolas Barraud¹, Bharat G Kardak, Nageshwar R Yepuri, Robert P Howlin, Jeremy S Webb, Saul N Faust, Staffan Kjelleberg, Scott A Rice, Michael J Kelso

Affiliation

¹ School of Biotechnology and Biomolecular Sciences and Centre for Marine Bio-Innovation, University of New South Wales, New South Wales, Australia.

PMID: 22890975
DOI: 10.1002/anie.201202414

Abstract

Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Biofilms / drug effects*
Cephalosporins / chemistry*
Nitric Oxide Donors / chemistry
Nitric Oxide Donors / pharmacology
Prodrugs / chemistry*
Prodrugs / pharmacology
Pseudomonas aeruginosa / physiology*
beta-Lactamases / metabolism

Substances

Anti-Bacterial Agents
Cephalosporins
Nitric Oxide Donors
Prodrugs
beta-Lactamases

Abstract

Publication types

MeSH terms

Substances

Grants and funding