Towards recyclable NAD(P)H regeneration catalysts

Molecules. 2012 Aug 15;17(8):9835-41. doi: 10.3390/molecules17089835.

Abstract

Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp*Rh(bpy)(H(2)O)](2+) was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors [NAD(P)H]. Repeated use of this catalyst was established and the catalytic properties were initially investigated. Apparently, Rh(III)-TsDPEN is prone to severe diffusion limitations, necessitating further developments. Overall, a promising concept for chemoenzymatic redox catalysis is proposed, which may overcome some of the current limitations such as catalyst cost and incompatibility of Rh with some biocatalysts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • NADP / metabolism*
  • Oxidation-Reduction

Substances

  • NADP