Adipose tissue houses different subtypes of stem cells

Can J Physiol Pharmacol. 2012 Sep;90(9):1295-301. doi: 10.1139/y2012-094. Epub 2012 Aug 22.

Abstract

Adipose tissue stromal fraction (ASF) contains multipotent cells capable of differentiation towards several lineages and may be used for the treatment of various degenerative diseases. However, the multipotent cells within ASF have not been fully characterized. In this study we have attempted to characterize stem cells in the ASF obtained through serial dilution. Five single-cell clones were studied. It was found that the single-cell clones exhibited slight but significant differences in proliferative capacity and differentiation potential. We conclude that ASF houses different subtypes of stem cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipogenesis / physiology
  • Animals
  • Antigens, CD / metabolism
  • Biomarkers / metabolism
  • Cell Culture Techniques
  • Cell Differentiation*
  • Cell Proliferation*
  • Cells, Cultured
  • Chondrogenesis / physiology
  • Clone Cells / cytology
  • Endothelium / cytology
  • Flow Cytometry
  • Green Fluorescent Proteins / genetics
  • Multipotent Stem Cells / cytology*
  • Osteogenesis / physiology
  • Rats
  • Rats, Inbred Lew
  • Rats, Transgenic
  • Single-Cell Analysis
  • Stromal Cells / cytology
  • Subcutaneous Fat / cytology*

Substances

  • Antigens, CD
  • Biomarkers
  • Green Fluorescent Proteins