Abstract
Two triterpenoidal saponins were isolated from the seeds of Momordica cochinchinensis Sprenger (Cucurbitaceae). Identification of chemical structures has been performed by (1)H- and (13)C-NMR spectroscopy and gas chromatography (GC). One of the saponins is a new gypsogenin glycoside, named as gypsogenin 3-O-β-D-galactopyranosyl(1→2)-[α-L-rhamnopyranosyl(1→3)]-β-D-glucuronopyranoside (compound 1), which is reported for the first time from natural resources. The other saponin is a quillaic acid glycoside (compound 2), which showed anti-inflammatory activities in RAW 264.7 cells. The mechanistic understanding of anti-inflammatory activities demonstrates that compound 2 inhibits lipopolysaccharide-induced expression of nitric oxide and IL-6 via NF-κB pathway.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Cell Line
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Chromatography, Gas / methods
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Glycosides / chemistry
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Glycosides / pharmacology*
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Interleukin-6 / immunology
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Interleukin-6 / metabolism
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Lipopolysaccharides / immunology
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Lipopolysaccharides / pharmacology*
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Macrophages / drug effects*
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Macrophages / immunology
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Macrophages / metabolism
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Magnetic Resonance Spectroscopy / methods
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Mice
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Momordica / chemistry*
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NF-kappa B / immunology
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NF-kappa B / metabolism
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Nitric Oxide / immunology
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Nitric Oxide / metabolism
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Oleanolic Acid / analogs & derivatives
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Oleanolic Acid / chemistry
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Oleanolic Acid / pharmacology
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Saponins / chemistry
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Saponins / pharmacology
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Seeds / chemistry
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Terpenes / chemistry
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Terpenes / pharmacology*
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Triterpenes / chemistry
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Triterpenes / pharmacology*
Substances
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Anti-Inflammatory Agents
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Glycosides
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Interleukin-6
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Lipopolysaccharides
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NF-kappa B
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Plant Extracts
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Saponins
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Terpenes
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Triterpenes
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Nitric Oxide
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quillaic acid
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Oleanolic Acid