Evolution of portal vein tumor thromboses in patients with hepatocellular carcinoma: CT findings and transition of serum tumor markers

Il Soo Chang; Sung Wook Shin; Sung Ki Cho; Hyunchul Rhim; Dongil Choi; Kwang Bo Park; Hong Suk Park; Sung Wook Choo; Young Soo Do; In-Wook Choo

doi:10.1016/j.clinimag.2011.11.020

Evolution of portal vein tumor thromboses in patients with hepatocellular carcinoma: CT findings and transition of serum tumor markers

Clin Imaging. 2012 Sep-Oct;36(5):489-95. doi: 10.1016/j.clinimag.2011.11.020. Epub 2012 Jun 8.

Authors

Il Soo Chang¹, Sung Wook Shin, Sung Ki Cho, Hyunchul Rhim, Dongil Choi, Kwang Bo Park, Hong Suk Park, Sung Wook Choo, Young Soo Do, In-Wook Choo

Affiliation

¹ Department of Radiology and Research Institute of Biomedical Science, Konkuk University School of Medicine, Seoul, Republic of Korea.

PMID: 22920351
DOI: 10.1016/j.clinimag.2011.11.020

Abstract

We investigated the patterns of evolution of portal vein tumor thromboses (PVTTs) and the changes in serum tumor marker levels in untreated hepatocellular carcinomas. The mean time required for the subsegmental or lower-order branch PVTTs and the segmental PVTTs to reach the large portal vein was 120 and 101 days, respectively. The mean values of the serum alpha-fetoprotein levels markedly increased after the appearance of PVTTs from 1858.7 ng/ml to 6795.2 ng/ml.

MeSH terms

Adult
Aged
Biomarkers, Tumor / blood
Carcinoma, Hepatocellular / complications*
Contrast Media
Disease Progression
Female
Humans
Liver Neoplasms / complications*
Male
Middle Aged
Portal Vein*
Retrospective Studies
Tomography, X-Ray Computed*
Venous Thrombosis / diagnostic imaging*
Venous Thrombosis / etiology*
alpha-Fetoproteins / metabolism

Substances

Biomarkers, Tumor
Contrast Media
alpha-Fetoproteins