Guanylate-binding proteins: niche recruiters for antimicrobial effectors

Christopher D Dupont; Christopher A Hunter

doi:10.1016/j.immuni.2012.08.005

Guanylate-binding proteins: niche recruiters for antimicrobial effectors

Immunity. 2012 Aug 24;37(2):191-3. doi: 10.1016/j.immuni.2012.08.005.

Authors

Christopher D Dupont¹, Christopher A Hunter

Affiliation

¹ Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA.

PMID: 22921115
DOI: 10.1016/j.immuni.2012.08.005

Abstract

There are fundamental questions regarding how IFN-γ activates host cells to eliminate intracellular pathogens. In this issue of Immunity, Yamamoto et al. (2012) demonstrate a critical role for the p65 guanylate-binding proteins (GBPs) in this process during infection with Toxoplasma gondii.

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