Molecular genetic analysis of influenza A/H3N2 virus strains isolated in Western Siberia in the 2010-2011 epidemic season

Infect Genet Evol. 2012 Dec;12(8):1694-8. doi: 10.1016/j.meegid.2012.07.014. Epub 2012 Aug 16.

Abstract

Molecular genetic and antigenic features of influenza A/H3N2 virus strains isolated in Western Siberia in 2011 are similar to those of the vaccine strain A/Perth/16/2009 despite a number of unique amino-acid changes. The strains lack specific amino-acid changes in NA protein providing decrease of sensibility to NA inhibitors activity that used in medical practice. Based on phylogenic analysis of HA protein amino-acid sequences examined strains are similar to influenza A/H3N2 virus strains circulating at the moment in Eurasia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Amino Acid Substitution
  • Child
  • Epidemics*
  • Female
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics
  • Humans
  • Influenza A Virus, H3N2 Subtype / classification
  • Influenza A Virus, H3N2 Subtype / genetics*
  • Influenza A Virus, H3N2 Subtype / isolation & purification
  • Influenza, Human / epidemiology*
  • Influenza, Human / virology*
  • Male
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Phylogeny
  • Siberia / epidemiology

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus