Phylogenetic analysis of the bovine parainfluenza virus type 3 from cattle herds revealing the existence of a genotype A strain in China

Virus Genes. 2012 Dec;45(3):542-7. doi: 10.1007/s11262-012-0810-1. Epub 2012 Aug 26.

Abstract

In 2009, a bovine parainfluenza virus (BPIV3), named as NM09, was isolated using MDBK cell culture from the nasal swabs of normal cattle in China. The NM09 isolate was characterized by RT-PCR and nucleotide sequence analysis. Its complete genome was 15,456 nucleotides in length. Similar to other sequenced PIV strains, the NM09 virus consisted of six non-overlapping genes, which were predicted to encode nine proteins with conserved and complementary 3' leader and 5' trailer regions, conserved gene starts, gene stops, and trinucleotide intergenic sequences. Nucleotide phylogenetic analysis of matrix and hemagglutinin-neuraminidase gene demonstrated that this NM09 isolate belonged to BPIV3 genotype A instead of the previously reported BPIV3 genotype C in China. It is implicated that the different genotypes A and C might coexist infection for a long time in China.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cattle / virology*
  • Cell Line
  • China
  • Genes, Viral
  • Genome Size
  • Genotype*
  • HN Protein / genetics
  • Parainfluenza Virus 3, Bovine / classification
  • Parainfluenza Virus 3, Bovine / genetics*
  • Parainfluenza Virus 3, Bovine / isolation & purification
  • Phylogeny*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Viral Matrix Proteins / genetics
  • Virus Cultivation / methods

Substances

  • HN Protein
  • Viral Matrix Proteins