Complete genome sequence of two coxsackievirus A1 strains that were cytotoxic to human rhabdomyosarcoma cells

Qiang Sun; Yong Zhang; Shuangli Zhu; Hui Cui; Huifang Tian; Dongmei Yan; Guohong Huang; Zhen Zhu; Dongyan Wang; Xiaolei Li; Huafang Jiang; Hongqiu An; Wenbo Xu

doi:10.1128/JVI.01567-12

Complete genome sequence of two coxsackievirus A1 strains that were cytotoxic to human rhabdomyosarcoma cells

J Virol. 2012 Sep;86(18):10228-9. doi: 10.1128/JVI.01567-12.

Authors

Qiang Sun¹, Yong Zhang, Shuangli Zhu, Hui Cui, Huifang Tian, Dongmei Yan, Guohong Huang, Zhen Zhu, Dongyan Wang, Xiaolei Li, Huafang Jiang, Hongqiu An, Wenbo Xu

Affiliation

¹ WHO WPRO Regional Polio Reference Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

Abstract

Coxsackievirus A1 (CVA1) belongs to human enterovirus species C within the family Picornaviridae, order Picornavirales. Two Chinese CVA1 isolates, HT-THLH02F/XJ/CHN/2011 and KS-ZPH01F/XJ/CHN/2011, were isolated from stool specimens of two healthy children in the Xinjiang Uygur autonomous region of China. They were found to elicit cytopathic effects in a human rhabdomyosarcoma cell line, and complete genome sequences of these two CVA1 isolates revealed that natural intertypic recombination events occurred between CVA1 and CVA22.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Child
China
Cytopathogenic Effect, Viral
Enterovirus C, Human / classification
Enterovirus C, Human / genetics*
Enterovirus C, Human / isolation & purification
Enterovirus C, Human / pathogenicity
Genome, Viral
Humans
Molecular Sequence Data
Phylogeny
Recombination, Genetic
Rhabdomyosarcoma

Associated data

GENBANK/JX174176
GENBANK/JX174177