Abstract
The transcriptional coactivators PGC-1α and PGC-1β are master regulators of oxidative phosphorylation and fatty acid oxidation gene expression. Pressure overload hypertrophy and heart failure are associated with repressed PGC-1α and PGC-1β gene expression. Maintaining expression of PGC-1α and -β preserves contractile function in response to a pathological increase in workload. Here, we discuss the regulation of PGC-1 proteins under conditions of pressure overload hypertrophy and heart failure.
Copyright © 2012 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Cardiomegaly / metabolism*
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Gene Expression Regulation
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Heart Failure / metabolism*
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Heat-Shock Proteins / genetics
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Heat-Shock Proteins / metabolism*
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Humans
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Mice
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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RNA-Binding Proteins
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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Carrier Proteins
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Heat-Shock Proteins
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PPARGC1A protein, human
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PPARGC1B protein, human
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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RNA-Binding Proteins
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Transcription Factors