Abstract
The anticancer activities of alkyl esters and NO-donors of ferulic acid (FA) and caffeic acid (CA) were assessed by a high-throughout screening (HTS) method, and the structure-activity relationships were described. CA alkyl esters had better anticancer activities than FA alkyl esters with the same alkyl substituent. Mono-nitrates and phenylfuroxan nitrates were more potent than the dual nitrates. Phenylsulfonylfuroxan nitrates of FA, especially compounds 8b-8d, exhibited more potent activities in anticancer.
Copyright © 2012. Published by Elsevier Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Caffeic Acids / chemical synthesis
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Caffeic Acids / chemistry*
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Caffeic Acids / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Coumaric Acids / chemical synthesis
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Coumaric Acids / chemistry*
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Coumaric Acids / pharmacology*
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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HeLa Cells
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High-Throughput Screening Assays
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Humans
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Molecular Structure
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Caffeic Acids
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Coumaric Acids
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ferulic acid
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caffeic acid