Abstract
The interaction of antigen-presenting cells with free peptides or a denatured protein can give rise to peptide-MHC class II complexes that are distinct from those generated after the processing of the whole protein. Such atypical peptide-MHC complexes can be recognized by unconventional 'type B' T cells that are not a component of the normal immune response to proteins. Importantly, these unconventional T cells can be found in the setting of autoimmunity. Here, we discuss unconventional peptide recognition by type B T cells and consider the implications for type 1 diabetes and other autoimmune diseases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigen Presentation / immunology
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Autoantigens / chemistry
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Autoantigens / immunology
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Autoimmunity*
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CD4-Positive T-Lymphocytes / immunology
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Epitopes, T-Lymphocyte / immunology
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Epitopes, T-Lymphocyte / metabolism
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Histocompatibility Antigens Class II / immunology
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Histocompatibility Antigens Class II / metabolism
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Humans
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Peptides / immunology*
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Peptides / metabolism
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T-Lymphocyte Subsets / immunology
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T-Lymphocytes / immunology*
Substances
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Autoantigens
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Epitopes, T-Lymphocyte
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Histocompatibility Antigens Class II
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Peptides