miRNA regulates noncoding RNA: a noncanonical function model

Xi Chen; Hongwei Liang; Chen-Yu Zhang; Ke Zen

doi:10.1016/j.tibs.2012.08.005

miRNA regulates noncoding RNA: a noncanonical function model

Trends Biochem Sci. 2012 Nov;37(11):457-9. doi: 10.1016/j.tibs.2012.08.005. Epub 2012 Sep 8.

Authors

Xi Chen¹, Hongwei Liang, Chen-Yu Zhang, Ke Zen

Affiliation

¹ Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093, China.

PMID: 22963870
DOI: 10.1016/j.tibs.2012.08.005

Abstract

It has long been assumed that miRNAs can only target protein-coding mRNAs in the cytoplasm. Recent studies, however, reveal miRNAs are also transported from the cytoplasm to the nucleus, where they function in a noncanonical manner to regulate noncoding RNAs. Here, we highlight the working model of these noncanonical miRNAs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biological Transport
Cell Nucleus / metabolism
Humans
MicroRNAs / metabolism*
Models, Biological
RNA Stability
RNA, Long Noncoding / agonists
RNA, Long Noncoding / antagonists & inhibitors
RNA, Long Noncoding / metabolism
RNA, Nuclear / agonists
RNA, Nuclear / antagonists & inhibitors
RNA, Nuclear / metabolism
RNA, Untranslated / agonists
RNA, Untranslated / antagonists & inhibitors
RNA, Untranslated / metabolism*

Substances

MicroRNAs
RNA, Long Noncoding
RNA, Nuclear
RNA, Untranslated