Abstract
Oxime Click chemistry was used to form hydrogels that support cell adhesion. Eight-armed aminooxy poly(ethylene glycol) (PEG) was mixed with glutaraldehyde to form oxime-linked hydrogels. The mechanical properties, gelation kinetics, and water swelling ratios were studied and found to be tunable. It was also shown that gels containing the integrin ligand arginine-glycine-aspartic acid (RGD) supported mesenchymal stem cell (MSC) incorporation. High cell viability and proliferation of the encapsulated cells demonstrated biocompatibility of the material.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Biocompatible Materials / chemical synthesis*
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Biocompatible Materials / chemistry
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Cell Proliferation
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Cell Survival
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Click Chemistry*
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Glutaral / chemistry
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Hydrogels / chemical synthesis*
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Hydrogels / chemistry
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Kinetics
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Mesenchymal Stem Cells / chemistry
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Oligopeptides / chemistry
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Oximes / chemical synthesis
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Oximes / chemistry*
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Polyethylene Glycols / chemistry
Substances
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Biocompatible Materials
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Hydrogels
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Oligopeptides
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Oximes
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Polyethylene Glycols
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arginyl-glycyl-aspartic acid
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Glutaral