Acute otitis media replacement and recurrence in the Finnish otitis media vaccine trial

Clin Infect Dis. 2012 Dec;55(12):1673-6. doi: 10.1093/cid/cis799. Epub 2012 Sep 12.

Abstract

We reanalyzed the 7-valent pneumococcal conjugate vaccine trial FinOM for prevention of acute otitis media (AOM), with a focus on disease replacement due to other pathogens and AOM recurrence. We found evidence of replacement disease occurring early during the trial follow-up and little vaccine impact on recurrent overall AOM episodes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Child, Preschool
  • Finland / epidemiology
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Humans
  • Infant
  • Otitis Media / epidemiology
  • Otitis Media / microbiology
  • Otitis Media / prevention & control*
  • Pneumococcal Vaccines / administration & dosage*
  • Recurrence

Substances

  • Heptavalent Pneumococcal Conjugate Vaccine
  • Pneumococcal Vaccines