Abstract
We reanalyzed the 7-valent pneumococcal conjugate vaccine trial FinOM for prevention of acute otitis media (AOM), with a focus on disease replacement due to other pathogens and AOM recurrence. We found evidence of replacement disease occurring early during the trial follow-up and little vaccine impact on recurrent overall AOM episodes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Child, Preschool
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Finland / epidemiology
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Heptavalent Pneumococcal Conjugate Vaccine
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Humans
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Infant
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Otitis Media / epidemiology
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Otitis Media / microbiology
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Otitis Media / prevention & control*
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Pneumococcal Vaccines / administration & dosage*
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Recurrence
Substances
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Heptavalent Pneumococcal Conjugate Vaccine
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Pneumococcal Vaccines