Breast cancer therapies and cardiomyopathy

Med Clin North Am. 2012 Sep;96(5):1001-19. doi: 10.1016/j.mcna.2012.07.008.

Abstract

The prevalence of chemotherapy-related cardiac disease is increasing and management demands a multidisciplinary approach from cardiologists and oncologists. Pretreatment identification of predisposing risk factors and assessment of cardiac function before and at intervals during and after therapy with cardiotoxic agents are necessary. In clinical practice, surveillance is largely performed using transthoracic echocardiography or multi-gated radionuclide angiography. Imaging strategies that detect cardiac injury before overt left ventricular systolic dysfunction provide an opportunity for early intervention and improved cardiac outcomes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anthracyclines / adverse effects*
  • Antibodies, Monoclonal, Humanized / adverse effects
  • Antineoplastic Agents / adverse effects*
  • Biomarkers / blood
  • Breast Neoplasms / drug therapy*
  • Cardiomyopathies / chemically induced*
  • Cardiomyopathies / diagnosis
  • Cardiomyopathies / drug therapy
  • Echocardiography
  • Female
  • Gated Blood-Pool Imaging
  • Heart / drug effects*
  • Humans
  • Receptor, ErbB-2 / antagonists & inhibitors
  • Risk Assessment
  • Trastuzumab

Substances

  • Anthracyclines
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents
  • Biomarkers
  • ERBB2 protein, human
  • Receptor, ErbB-2
  • Trastuzumab