Synthetic chloride transporters with the binding mode observed in a ClC chloride channel

Chem Commun (Camb). 2012 Oct 25;48(83):10346-8. doi: 10.1039/c2cc35743g.

Abstract

A series of synthetic molecules bearing the same hydrogen bonding mode observed in StClC were prepared and their transport ability of chloride ion across a lipid membrane was systematically optimized.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Chloride Channels / chemistry
  • Chloride Channels / metabolism*
  • Chlorides / chemistry
  • Chlorides / metabolism*
  • Hydrogen Bonding
  • Ions / chemistry
  • Ions / metabolism
  • Lipid Bilayers / chemistry
  • Lipid Bilayers / metabolism
  • Quaternary Ammonium Compounds / chemical synthesis*
  • Quaternary Ammonium Compounds / chemistry
  • Quaternary Ammonium Compounds / metabolism
  • Salmonella typhimurium / metabolism

Substances

  • CLC-1 channel
  • Chloride Channels
  • Chlorides
  • Ions
  • Lipid Bilayers
  • Quaternary Ammonium Compounds
  • tetrabutylammonium