Tormentic acid derivatives: synthesis and apoptotic activity

Eur J Med Chem. 2012 Oct:56:237-45. doi: 10.1016/j.ejmech.2012.08.032. Epub 2012 Aug 31.

Abstract

Several derivatives of tormentic acid have been prepared and tested for their antitumor activity. The dichloroacetate 14 is an excellent antitumor active agent acting by an apoptose inducing pathway as demonstrated by OA/PI staining, DNA laddering experiments as well as by an annexin V binding assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Humans
  • MCF-7 Cells
  • Mice
  • Molecular Conformation
  • NIH 3T3 Cells
  • Structure-Activity Relationship
  • Triterpenes / chemical synthesis
  • Triterpenes / chemistry
  • Triterpenes / pharmacology*

Substances

  • Antineoplastic Agents
  • Triterpenes
  • euscaphic acid