Abstract
We report here the first novel HIV-1 circulating recombinant form (CRF) 54_01B (CRF54_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B' and CRF01_AE, with identical recombination breakpoints observed in the gag, pol, and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the subtype B' and CRF01_AE lineages and indicates the potential of the new CRF in bridging HIV-1 transmission among different risk groups in Southeast Asia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Genetic Variation
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Genome, Viral*
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HIV Infections / virology*
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HIV-1 / classification
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HIV-1 / genetics*
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HIV-1 / isolation & purification
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Humans
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Malaysia
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Molecular Sequence Data
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RNA, Viral / analysis
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RNA, Viral / genetics
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Recombination, Genetic
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Sequence Analysis, RNA
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gag Gene Products, Human Immunodeficiency Virus / genetics
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pol Gene Products, Human Immunodeficiency Virus / genetics
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vif Gene Products, Human Immunodeficiency Virus / genetics
Substances
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RNA, Viral
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gag Gene Products, Human Immunodeficiency Virus
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pol Gene Products, Human Immunodeficiency Virus
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vif Gene Products, Human Immunodeficiency Virus
Associated data
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GENBANK/JX390976
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GENBANK/JX390977