Abstract
The study of diabetic cardiomyopathy is an area of significant interest given the strong association between diabetes and the risk of heart failure. Many unanswered questions remain regarding the clinical definition and pathogenesis of this metabolic cardiomyopathy. This article reviews the current understanding of diabetic cardiomyopathy with a particular emphasis on the unresolved issues that have limited translation of scientific discovery to patient bedside.
Copyright © 2012 Elsevier Inc. All rights reserved.
MeSH terms
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Diabetes Mellitus / drug therapy
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Diabetes Mellitus / pathology*
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Diabetic Cardiomyopathies / drug therapy
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Diabetic Cardiomyopathies / etiology*
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Diabetic Cardiomyopathies / metabolism
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Disease Progression
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Fatty Acids, Nonesterified / metabolism
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Humans
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Inflammation
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Lipid Metabolism
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Male
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Middle Aged
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Mitochondria / metabolism
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Mitochondria / pathology
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Myocardial Infarction / etiology
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Myocardium / metabolism
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Myocardium / pathology*
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Oxidative Stress
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Prognosis
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Risk Factors
Substances
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Fatty Acids, Nonesterified