Treg cells acquire new directions, cytokines navigate

Naganari Ohkura; Shimon Sakaguchi

doi:10.1016/j.immuni.2012.09.004

Treg cells acquire new directions, cytokines navigate

Immunity. 2012 Sep 21;37(3):443-4. doi: 10.1016/j.immuni.2012.09.004.

Authors

Naganari Ohkura¹, Shimon Sakaguchi

Affiliation

¹ Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.

PMID: 22999950
DOI: 10.1016/j.immuni.2012.09.004

Abstract

Foxp3(+) Treg cells express transcription factors normally expressed by specific T helper cells at sites of inflammation. In this issue of Immunity, Koch et al. (2012) and Hall et al. (2012) demonstrate that IFN-γ and IL-27 distinctly induces T-bet(+) Treg cells via STAT-1 transcription factor activation.

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