Eggshell-inspired biomineralization generates vaccines that do not require refrigeration

Guangchuan Wang; Xiaofeng Li; Lijuan Mo; Zhiyong Song; Wei Chen; Yongqiang Deng; Hui Zhao; Ede Qin; Chengfeng Qin; Ruikang Tang

doi:10.1002/anie.201206154

Eggshell-inspired biomineralization generates vaccines that do not require refrigeration

Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10576-9. doi: 10.1002/anie.201206154. Epub 2012 Sep 24.

Authors

Guangchuan Wang¹, Xiaofeng Li, Lijuan Mo, Zhiyong Song, Wei Chen, Yongqiang Deng, Hui Zhao, Ede Qin, Chengfeng Qin, Ruikang Tang

Affiliation

¹ Center for Biomaterials and Biopathways, Zhejiang University, Hangzhou, Zhejiang 310027, China.

PMID: 23002021
DOI: 10.1002/anie.201206154

Abstract

We're not gonna bake it: In situ biomineralization creates an egg-like shell on vaccine particles to improve their thermostability. Different from the bare vaccine (squares), the biomineralized vaccine (red circles) can be stored at ambient temperature without refrigeration for up to a week and retain biological activity both in vitro (see graph), as well as in a mouse model.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Drug Stability
Drug Storage / standards
Egg Shell / chemistry*
Egg Shell / immunology*
Mice
Mice, Inbred BALB C
Refrigeration*
Vaccines / chemistry*

Substances

Vaccines