Abstract
[2,5-Dimethylfuran]-protected maleimides were placed at both internal positions and the 3'-end of oligonucleotides making use of solid-phase synthesis procedures. A new phosphoramidite derivative and a new solid support incorporating the protected maleimide moiety were prepared for this purpose. In all cases maleimide deprotection (retro-Diels-Alder reaction) followed by reaction with thiol-containing compounds afforded the target conjugate.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Furans / chemical synthesis
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Furans / chemistry*
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Maleimides / chemical synthesis
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Maleimides / chemistry*
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Oligonucleotides / chemical synthesis
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Oligonucleotides / chemistry*
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Organophosphorus Compounds / chemical synthesis
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Organophosphorus Compounds / chemistry*
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Solid-Phase Synthesis Techniques*
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Sulfhydryl Compounds / chemical synthesis
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Sulfhydryl Compounds / chemistry
Substances
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Furans
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Maleimides
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Oligonucleotides
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Organophosphorus Compounds
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Sulfhydryl Compounds
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phosphoramidite
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maleimide
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2,5-dimethylfuran