Foamy gland pancreatic ductal adenocarcinoma diagnosed on EUS-FNA: a histochemical, immunohistochemical, and molecular report

Claudio Bellevicine; Umberto Malapelle; Antonino Iaccarino; Pietro Schettino; Vincenzo Napolitano; Pio Zeppa; Giancarlo Troncone

doi:10.1002/dc.22923

Foamy gland pancreatic ductal adenocarcinoma diagnosed on EUS-FNA: a histochemical, immunohistochemical, and molecular report

Diagn Cytopathol. 2013 Jan;41(1):77-80. doi: 10.1002/dc.22923. Epub 2012 Sep 25.

Authors

Claudio Bellevicine¹, Umberto Malapelle, Antonino Iaccarino, Pietro Schettino, Vincenzo Napolitano, Pio Zeppa, Giancarlo Troncone

Affiliation

¹ Department of Biomorfologic and Functional Sciences, University of Naples Federico II, Naples, Italy.

PMID: 23008087
DOI: 10.1002/dc.22923

Abstract

The foamy gland pattern (FGP) may impart to pancreatic ductal adenocarcinoma (PDA) a deceptively benign appearance. Thus, its diagnosis on FNA is challenging. A case of PDA with FGP, that was suspected on Diff Quik smears, diagnosed on cell-block preparation and confirmed by ancillary stains and molecular techniques, is here reported. The diagnostic interpretation of foamy atypical cells on direct smears may benefit from cell block preparation and from ancillary techniques.

Publication types

Case Reports

MeSH terms

Adenocarcinoma / diagnosis*
Adenocarcinoma / pathology
Carcinoma, Pancreatic Ductal / diagnosis*
Carcinoma, Pancreatic Ductal / pathology
Cell Nucleus / pathology
Cytoplasm / pathology
Endoscopic Ultrasound-Guided Fine Needle Aspiration*
False Negative Reactions
Female
Humans
Middle Aged
Mutation
Pancreatic Neoplasms / diagnosis*
Pancreatic Neoplasms / pathology
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins p21(ras)
Sequence Analysis, DNA
ras Proteins / genetics

Substances

KRAS protein, human
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)
ras Proteins