Abstract
Using a photosensitive hybrid hydrogel loaded with upconversion nanoparticles (UCNPs), we show that continuous-wave near-infrared (NIR) light (980 nm) can be used to induce the gel-sol transition and release large, inactive biomacromolecules (protein and enzyme) entrapped in the hydrogel into aqueous solution "on demand", where their bioactivity is recovered. This study is a new demonstration and development in harnessing the unique multiphoton effect of UCNPs for photosensitive materials of biomedical interest.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cattle
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Delayed-Action Preparations / chemistry*
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Fluorescein-5-isothiocyanate / administration & dosage
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Fluorescein-5-isothiocyanate / analogs & derivatives*
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Hydrogels / chemistry*
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Infrared Rays
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Light
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Nanoparticles / chemistry*
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Phase Transition
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Serum Albumin, Bovine / administration & dosage*
Substances
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Delayed-Action Preparations
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Hydrogels
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fluorescein isothiocyanate bovine serum albumin
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Serum Albumin, Bovine
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Fluorescein-5-isothiocyanate